US 12,070,532 B2
Nitric oxide and chlorhexidine releasing catheter for anti-platelet and antimicrobial dual functionality
James Freasier, Salt Lake City, UT (US); Brendan Laine, Salt Lake City, UT (US); and Gidon Ofek, Millcreek, UT (US)
Assigned to Becton, Dickinson and Company, Franklin Lakes, NJ (US)
Filed by Becton, Dickinson and Company, Franklin Lakes, NJ (US)
Filed on Nov. 9, 2020, as Appl. No. 17/093,451.
Claims priority of provisional application 62/936,935, filed on Nov. 18, 2019.
Prior Publication US 2021/0146014 A1, May 20, 2021
Int. Cl. A61L 29/08 (2006.01); A61L 29/04 (2006.01)
CPC A61L 29/085 (2013.01) [A61L 29/049 (2013.01); A61L 2300/114 (2013.01); A61L 2300/404 (2013.01); A61L 2300/42 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of manufacturing a catheter configured to release nitric oxide and chlorhexidine to provide anti-platelet and antimicrobial properties, comprising:
impregnating a thermoplastic polyurethane catheter extrusion with a nitric oxide releasing compound and with chlorhexidine, wherein the impregnating step comprises:
obtaining an impregnating solution comprising the nitric oxide releasing compound and chlorhexidine dissolved in an impregnating solvent, wherein the impregnating solvent comprises methanol, acetone, and methyl ethyl ketone (MEK); and
exposing the thermoplastic polyurethane catheter extrusion to the impregnating solution for sufficient time to permit the nitric oxide releasing compound and chlorhexidine to penetrate the thermoplastic polyurethane catheter extrusion; and
evaporating the solvent from the catheter extrusion; and
coating the impregnated catheter extrusion with a polyurethane coating comprising chlorhexidine, wherein the coating step comprises dipping the catheter extrusion into a polymer solution comprising polyurethane and chlorhexidine dissolved in a dip coating solvent wherein the dip coating solvent comprises methanol and dioxolane.