	US 12,070,497 B2
	Hepatitis B vaccine transnasal administration system
Taizou Kamishita, Osaka (JP); Takashi Miyazaki, Osaka (JP); Yoichi Hiasa, Toon (JP); Fazle Akbar Sheikh Mohammad, Toon (JP); Osamu Yoshida, Toon (JP); Julio Cesar Aguilar Rubido, Ciudad de la Habana (CU); Gerardo Enrique Guillen Nieto, Ciudad de la Habana (CU); and Eduardo Penton Arias, Ciudad de la Habana (CU)
Assigned to TOKO YAKUHIN KOGYO CO., LTD., Osaka (JP); NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, Matsuyama (JP); and CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA, Ciudad de la Habana (CU)
Appl. No. 15/734,148
Filed by TOKO YAKUHIN KOGYO CO., LTD., Osaka (JP); NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, Matsuyama (JP); and CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA, Ciudad de la Habana (CU)
PCT Filed Jun. 4, 2019, PCT No. PCT/JP2019/022136 § 371(c)(1), (2) Date Dec. 1, 2020, PCT Pub. No. WO2019/235466, PCT Pub. Date Dec. 12, 2019.
Claims priority of application No. 2018-107797 (JP), filed on Jun. 5, 2018.
Prior Publication US 2021/0187101 A1, Jun. 24, 2021
Int. Cl. C12N 5/00 (2006.01); A61K 9/12 (2006.01); A61K 39/12 (2006.01); A61K 39/29 (2006.01); A61K 47/32 (2006.01)

CPC A61K 39/29 (2013.01) [A61K 9/12 (2013.01); A61K 47/32 (2013.01)]

16 Claims

1. A rhinovaccination system of hepatitis B vaccine, comprising a syringe-based squirt filled with a hepatitis B vaccine composition which comprises (i) hepatitis B surface antigen (HBs antigen) and/or hepatitis B nucleocapsid antigen (HBc antigen), and (ii) a gel base material comprising carboxy vinyl polymer which is treated by adding an outside shearing force to add spray-performance.