US 12,070,483 B2
Compositions and methods for treatment of acute lung injury
Aron B. Fisher, Philadelphia, PA (US); and Sheldon I. Feinstein, Philadelphia, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Appl. No. 17/269,097
Filed by THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
PCT Filed Aug. 15, 2019, PCT No. PCT/US2019/046698
§ 371(c)(1), (2) Date Feb. 17, 2021,
PCT Pub. No. WO2020/037146, PCT Pub. Date Feb. 20, 2020.
Claims priority of provisional application 62/719,217, filed on Aug. 17, 2018.
Prior Publication US 2021/0315964 A1, Oct. 14, 2021
Int. Cl. A61K 38/00 (2006.01); A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61P 11/00 (2006.01)
CPC A61K 38/08 (2013.01) [A61K 38/10 (2013.01); A61P 11/00 (2018.01)] 19 Claims
 
1. A composition comprising a polypeptide consisting of:
 
 SEQ ID NO: 4
 
 X1X2X3X4X5LX6X7X8X9HQIL
wherein:
X1 may be present or absent and if present is E;
X2 may be present or absent and if present is L;
X3 may be present or absent and if present is Q;
X4 may be present or absent and if present is A or T;
X5 may be present or absent and if present is T or E;
X6 is H or Y;
X7 is D or E;
X8 is F or I; and
X9 is R or K.