US 12,070,411 B2
Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells
Mitchell E. Levinson, Pleasanton, CA (US); Donald Johnson, Danville, CA (US); Jessica Preciado, Alameda, CA (US); Edward A. Ebbers, San Carlos, CA (US); and Daniel Bucks, Millbrae, CA (US)
Assigned to Zeltiq Aesthetics, Inc., North Chicago, IL (US)
Filed by Zeltiq Aesthetics, Inc., Pleasanton, CA (US)
Filed on Oct. 8, 2019, as Appl. No. 16/595,466.
Application 16/595,466 is a continuation of application No. 13/747,161, filed on Jan. 22, 2013, abandoned.
Application 13/747,161 is a continuation of application No. 11/741,271, filed on Apr. 27, 2007, abandoned.
Claims priority of provisional application 60/795,799, filed on Apr. 28, 2006.
Prior Publication US 2020/0155215 A1, May 21, 2020
Int. Cl. A61F 7/00 (2006.01); A61B 18/00 (2006.01); A61B 18/02 (2006.01); A61B 18/12 (2006.01); A61B 18/20 (2006.01); A61F 7/02 (2006.01); A61F 7/10 (2006.01); A61B 90/00 (2016.01)
CPC A61F 7/00 (2013.01) [A61B 18/02 (2013.01); A61B 18/12 (2013.01); A61B 18/203 (2013.01); A61F 7/10 (2013.01); A61B 2018/00047 (2013.01); A61B 2018/00101 (2013.01); A61B 2018/00107 (2013.01); A61B 2018/00464 (2013.01); A61B 2018/00642 (2013.01); A61B 2018/00714 (2013.01); A61B 2018/00744 (2013.01); A61B 2018/00791 (2013.01); A61B 2018/0231 (2013.01); A61B 90/04 (2016.02); A61F 2007/0001 (2013.01); A61F 2007/0075 (2013.01); A61F 2007/0219 (2013.01); A61F 2007/0246 (2013.01); A61F 2007/029 (2013.01)] 24 Claims
OG exemplary drawing
 
12. A system for removing heat from subcutaneous lipid rich cells of a target region of a subject having skin, comprising:
a treatment device having a housing and a thermal mass in thermal communication with a heat exchanging surface, the thermal mass being configured to reduce a temperature of the target region for up to about 30 minutes such that lipid rich cells in the target region are affected while preserving non-lipid rich cells proximate to the heat exchanging surface;
an absorbent configured to be positioned at least partially between the heat exchanging surface and the subject's skin, the absorbent being preloaded with an excess of a cryoprotectant to continually supply the excess of cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced, wherein the cryoprotectant comprises about 40% propylene glycol and further comprises 0.8% hydroxyethylcellulose.