US 12,070,322 B2
Method for determining skin condition based on thermal sensitivity in skin
Ki Sai, Kanagawa (JP); Shigeyoshi Fujiwara, Kanagawa (JP); Hirofumi Aoki, Kanagawa (JP); and Takeshi Hariya, Kanagawa (JP)
Assigned to Shiseido Company, Ltd., Tokyo (JP)
Appl. No. 16/966,281
Filed by Shiseido Company, Ltd., Tokyo (JP)
PCT Filed Jan. 28, 2019, PCT No. PCT/JP2019/002804
§ 371(c)(1), (2) Date Jul. 30, 2020,
PCT Pub. No. WO2019/151197, PCT Pub. Date Aug. 8, 2019.
Claims priority of application No. 2018-014007 (JP), filed on Jan. 30, 2018.
Prior Publication US 2020/0367804 A1, Nov. 26, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/01 (2006.01)
CPC A61B 5/443 (2013.01) [A61B 5/01 (2013.01); A61B 2562/0271 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method for determining a transepidermal water loss value, the method comprising:
(a) applying a variable temperature probe to an area of a skin of a subject;
(b) changing a temperature of the variable temperature probe applied to the area of the skin of the subject from a preset temperature value, which is a temperature of the area of the skin of the subject;
(c) determining a sensed temperature value, which is a value of the temperature of the variable temperature probe applied to the area of the skin of the subject, at which value the subject senses the changing;
(d) calculating a sensed temperature difference for the area of the skin of the subject as a difference between the sensed temperature value and the preset temperature value; and
(e) determining a transepidermal water loss in the area of the skin of the subject based on the calculated sensed temperature difference for the area of the skin of the subject from a pre-determined relationship between a transepidermal water loss and a sensed temperature difference for a population of subjects for the same skin area, wherein the predetermined relationship provides a transepidermal water loss value for each of a plurality of temperature difference intervals; and wherein said determining (e) further comprises identifying a temperature difference interval among said plurality to which the sensed temperature difference belongs, and assigning a transepidermal water loss value that corresponds to the identified temperature difference interval according to the predetermined relationship as a value of the transepidermal water loss in the area of the skin of the subject.