US 12,070,281 B2
Methods and systems to control particles and implantable devices
Michael Shpigelmacher, Los Angeles, CA (US); Alex Kiselyov, San Diego, CA (US); Leslie Field, Portola Valley, CA (US); Mateusz Bryning, San Jose, CA (US); and Phillip Barth, Portola Valley, CA (US)
Assigned to BIONAUT LABS LTD., (IL)
Appl. No. 16/620,748
Filed by BIONAUT LABS LTD., Herzliya (IL)
PCT Filed May 3, 2018, PCT No. PCT/US2018/030960
§ 371(c)(1), (2) Date Dec. 9, 2019,
PCT Pub. No. WO2019/005293, PCT Pub. Date Jan. 3, 2019.
Claims priority of provisional application 62/524,650, filed on Jun. 26, 2017.
Prior Publication US 2020/0196995 A1, Jun. 25, 2020
Int. Cl. A61M 37/00 (2006.01); A61B 5/00 (2006.01); A61B 10/02 (2006.01); A61B 34/30 (2016.01); A61M 5/142 (2006.01); A61B 17/00 (2006.01); A61N 5/10 (2006.01)
CPC A61B 34/30 (2016.02) [A61B 5/0002 (2013.01); A61B 10/02 (2013.01); A61M 5/14276 (2013.01); A61M 37/0069 (2013.01); A61B 2010/0208 (2013.01); A61B 2017/00345 (2013.01); A61B 2017/00411 (2013.01); A61B 2034/303 (2016.02); A61B 2560/0214 (2013.01); A61B 2562/028 (2013.01); A61M 2205/0244 (2013.01); A61M 2205/0288 (2013.01); A61M 2205/0294 (2013.01); A61N 5/1007 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A platform comprising the following modules:
one or more particles, each of said particles having a size between about 100 nm and about 1000 μm and comprising embedded logic and microelectromechanical (MEM) components, each of said particles further comprising a remote power-harvesting component configured to harvest power from ultrasonic signals of a predetermined frequency to power said MEM components thereof;
a delivery and retraction module configured to deliver and retract said particles;
an external signal generator;
an imaging module configured to monitor said particles; and
an integration module configured to receive inputs from and to provide output control commands to said particles, said delivery and retraction module, said external signal generator and said imaging module;
wherein:
said particles, said delivery and retraction module, said external signal generator, said imaging module, and said integration module are configured to interact/communicate with each other; and are controlled internally and/or externally, thereby providing pre-determined, fully controlled, precise delivery of said particles in vitro, in vivo, and/or in a patient; and
the power-harvesting component comprises a flexible element having a resonance frequency which is equal to said predetermined frequency and a piezoelectric element connected to said flexible element.