US 12,070,265 B2
Electroporation system and method of preconditioning tissue for electroporation therapy
Jeff Schweitzer, St. Paul, MN (US); and Gregory K. Olson, Elk River, MN (US)
Assigned to St. Jude Medical, Cardiology Division, Inc., St. Paul, MN (US)
Filed by St. Jude Medical, Cardiology Division, Inc., St. Paul, MN (US)
Filed on Aug. 3, 2022, as Appl. No. 17/880,087.
Application 17/880,087 is a continuation of application No. 15/947,091, filed on Apr. 6, 2018, granted, now 11,432,871.
Claims priority of provisional application 62/483,743, filed on Apr. 10, 2017.
Prior Publication US 2022/0370125 A1, Nov. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 18/12 (2006.01); A61B 18/14 (2006.01); A61B 18/16 (2006.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/1492 (2013.01) [A61B 18/1206 (2013.01); A61B 18/16 (2013.01); A61N 1/0452 (2013.01); A61N 1/36042 (2013.01); A61B 2018/0016 (2013.01); A61B 2018/00178 (2013.01); A61B 2018/00351 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00839 (2013.01); A61B 2018/00958 (2013.01); A61B 2018/1266 (2013.01); A61B 2018/144 (2013.01); A61B 2018/165 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An electroporation generator for delivering electroporation therapy to a patient, the electroporation generator comprising:
an electroporation circuit configured to be coupled to a catheter for delivering the electroporation therapy to target cardiac tissue of the patient, the electroporation circuit further configured to transmit an electroporation signal through the catheter;
a stimulation circuit configured to be coupled to a stimulation electrode for stimulating skeletal muscle tissue in a thorax region of the patient that is proximate the target cardiac tissue, the stimulation circuit further configured to transmit a stimulation signal to the stimulation electrode; and
a controller coupled to the electroporation circuit and the stimulation circuit, the controller configured to synchronize transmissions of the electroporation signal and the stimulation signal, the controller further configured to determine at least one of a frequency or a voltage for the stimulation signal based on the skeletal muscle tissue being located in the thorax region of the patient.