a first ligating member configured to encircle and cut off blood flow to a first portion of a target tissue, the first ligating member structured to move from a first position maintaining configuration in which the first ligating member is configured to be tightened to a first level of tightness, wherein the first level of tightness is sufficient to hold the device in a first position and to maintain a desired position of the first ligating member around, and in contact with, the first portion of the target tissue without significantly cutting off blood flow to the first portion of the target tissue and without causing swelling around the first portion of the target tissue, and a second configuration in which the first ligating member is configured to be cinched down around the first portion of the target tissue to a second level of tightness sufficient to substantially cut off blood flow to the encircled first portion of the target tissue;

a first applicator including a proximal lumen and first and second opposed distal lumens open to the proximal lumen, the first ligating member extending from a proximal end distally through the proximal lumen of the first applicator into the first distal lumen of the first applicator to exit a distal end of the first distal lumen of the first applicator to loop around and enter the distal end of the second distal lumen of the first applicator, the first ligating member passing through the second distal lumen of the first applicator into the proximal lumen of the first applicator; and

a first hub through which a proximal portion of the first ligating member passes from the proximal lumen of the first applicator to the first distal lumen of the first applicator, a distal portion of the first ligating member re-entering the first hub to pass from the second distal lumen of the first applicator to the proximal lumen of the first applicator,

wherein the first hub and the first ligating member are configured so that the first hub locks the first ligating member in a desired position to maintain a desired compression on tissue received between the first applicator and a portion of the first ligating member extending between the distal ends of the first and second distal lumens of the first applicator, and

wherein the first hub includes a first ratchet mechanism and a first actuation switch which, when moved from a first position in which an engagement member of the first ratchet mechanism prevents a loosening of a loop of the first ligating member to a second position that moves the engagement member of the first ratchet mechanism out of engagement with the first ligating member to permit the first ligating member to move through the first hub in tightening and loosening directions.