CPC G01N 33/57438 (2013.01) | 12 Claims |
1. A method of treating a patient afflicted with pancreatic ductal adenocarcinoma having a stroma comprising cancer associated fibroblasts producing transforming growth factor β-induced protein (βig-h3), comprising
selecting an anti-βig-h3 neutralizing antibody capable of binding to stroma-produced βig-h3 protein and inhibiting interaction between stroma-produced βig-h3 protein and αVβ3 integrin,
administering to the patient a therapeutically effective amount of the anti-βig-h3 neutralizing antibody binding to stroma-produced βig-h3 protein and inhibiting interaction between stroma-produced βig-h3 protein and αVβ3 integrin,
obtaining specific binding of said anti-βig-h3 neutralizing antibody to stroma-produced βig-h3,
inhibiting interaction between stroma-produced βig-h3 protein and αVβ3 integrin, and
inhibiting the inhibition of cluster of differentiation 8 (CD8)+T cell activation.
|