US 11,740,229 B2
Method and system for determining biomarker concentration
Jan Vanfleteren, Gentbrugge (BE); and Patricia Khashayar, Ghent (BE)
Assigned to UNIVERSITEIT GENT, Ghent (BE); and IMEC VZW, Leuven (BE)
Appl. No. 16/482,962
Filed by UNIVERSITEIT GENT, Ghent (BE); and IMEC VZW, Leuven (BE)
PCT Filed Jan. 26, 2018, PCT No. PCT/EP2018/051969
§ 371(c)(1), (2) Date Aug. 1, 2019,
PCT Pub. No. WO2018/141645, PCT Pub. Date Aug. 9, 2018.
Claims priority of application No. 17154242 (EP), filed on Feb. 1, 2017.
Prior Publication US 2020/0232968 A1, Jul. 23, 2020
Int. Cl. G01N 33/49 (2006.01); G01N 27/06 (2006.01); G01N 33/487 (2006.01)
CPC G01N 33/492 (2013.01) [G01N 27/06 (2013.01); G01N 33/48707 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for deriving a calibration curve for determining a concentration of an analyte in an electrochemical reactor with a given design, the method comprising:
determining a current level, measured after a predetermined amount of time, between a functionalized electrode and a reference electrode in said electrochemical reactor in absence of an analyte, said current level forming a zero-concentration current,
injecting a fluid comprising an analyte in a first given concentration in said electrochemical reactor, determining after said predetermined amount of time a first calibration current level corresponding to said first given concentration and calculating a first current ratio of said first current level to said zero-concentration current,
repeating the previous step for at least a second given concentration of said analyte, yielding at least a second current ratio of a second current level to said zero-concentration current,
obtaining a calibration curve indicative of current ratio as a function of concentration from said first current ratio and at least said second current ratio, said current ratio being constant for electrochemical reactors with the given design.