US 11,740,181 B2
Preparation device, diagnostic apparatus, diagnostic kit and diagnostic system
Angelica Kohlmann, Zürich (CH); and Thomas Vincent Küpper, Zürich (CH)
Assigned to BLOOM DIAGNOSTICS AG, Zurich (CH)
Appl. No. 16/765,269
Filed by BLOOM DIAGNOSTICS AG, Zürich (CH)
PCT Filed Dec. 13, 2018, PCT No. PCT/EP2018/084828
§ 371(c)(1), (2) Date May 19, 2020,
PCT Pub. No. WO2019/115725, PCT Pub. Date Jun. 20, 2019.
Claims priority of application No. 01514/17 (CH), filed on Dec. 13, 2017.
Prior Publication US 2020/0371031 A1, Nov. 26, 2020
Int. Cl. G01N 21/64 (2006.01); G01N 21/84 (2006.01); G01N 33/74 (2006.01); G01N 33/543 (2006.01); G01N 21/01 (2006.01)
CPC G01N 21/6428 (2013.01) [G01N 21/8483 (2013.01); G01N 33/54388 (2021.08); G01N 33/74 (2013.01); G01N 2021/0118 (2013.01); G01N 2021/6436 (2013.01); G01N 2021/6439 (2013.01); G01N 2021/8494 (2013.01); G01N 2800/367 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A diagnostic apparatus for the measurement of a quantity of a target biomolecule in a probe of a bodily fluid prepared by a preparation device that is configured to prepare a sample for measurement of the target biomolecule in the probe of the bodily fluid,
the preparation device comprising:
a substrate with a capillary network configured to transport the probe of the bodily fluid along the substrate,
wherein the substrate is provided with a fluorescent, reflective or self-luminescent marker that is configured to bind with the target biomolecule to emit a reaction radiation, such that when the fluorescent, reflective or self-luminescent marker is bound to the target biomolecule together they are configured to emit the reaction radiation at an intensity proportional to the quantity of the target biomolecule in the probe of the bodily fluid, and
the diagnostic apparatus comprising:
a housing having a seat arranged to accommodate the preparation device in a predefined position and orientation;
an excitation source adapted to illuminate the substrate of the preparation device;
an optical assembly adapted to measure power spectral intensity values of a reaction radiation emitted by a product of reaction on the preparation device, wherein the power spectral intensity values are proportional to the quantity of the target biomolecule in the probe of the bodily fluid; and
an electronic assembly adapted to process and convert the power spectral intensity values measured by the optical assembly to a quantity value of the target biomolecule in the probe of the bodily fluid,
wherein the electronic assembly comprises a data exchange equipment adapted to receive data from the preparation device and to send data to a remote handheld communication device adapted to receive and display the quantity value of the target biomolecule in the probe of the bodily fluid, and
wherein, when the preparation device is arranged in the seat of the housing, the optical assembly is arranged to ensure a first measurement alignment between the excitation source and the substrate of the preparation device illuminated by the excitation source and to ensure a second measurement alignment between the substrate of the preparation device emitting a reaction light and the electronic assembly.