	US 11,739,349 B2
	Primate retinal pigment epithelium cell-specific promoter
Josephine Juettner, Basel (CH); Jacek Krol, Basel (CH); and Botond Roska, Oberwil (CH)
Assigned to Friedrich Miescher Institute for Biomedical Research, Basel (CH)
Appl. No. 16/764,306
Filed by FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel (CH)
PCT Filed Nov. 15, 2018, PCT No. PCT/IB2018/059015 § 371(c)(1), (2) Date May 14, 2020, PCT Pub. No. WO2019/097454, PCT Pub. Date May 23, 2019.
Claims priority of application No. 17201828 (EP), filed on Nov. 15, 2017.
Prior Publication US 2021/0054408 A1, Feb. 25, 2021
Int. Cl. C12N 15/86 (2006.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); C07K 14/705 (2006.01)

CPC C12N 15/86 (2013.01) [A61K 38/177 (2013.01); A61K 48/0058 (2013.01); C07K 14/705 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/008 (2013.01); C12N 2830/15 (2013.01)]

34 Claims

1. A method for expressing an exogenous gene in a retinal pigment epithelial cell of a primate, the method comprising delivering to the retinal pigment epithelial cell of the primate an expression cassette comprising a nucleic acid sequence of at least 400 bp and having at least 95% overall identity to the nucleic acid sequence of SEQ ID NO:1, operatively linked to a nucleic acid sequence coding for the exogenous gene,

wherein the nucleic acid sequence of at least 400 bp and having at least 95% overall identity to the nucleic acid sequence of SEQ ID NO:1 is effective to drive expression of the exogenous gene in the retinal pigment epithelial cell of the primate.