CPC C12N 15/113 (2013.01) [A61K 9/0048 (2013.01); A61K 31/4025 (2013.01); A61K 31/5513 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); A61P 27/02 (2018.01); G01N 33/6893 (2013.01); C12N 2310/14 (2013.01); G01N 2333/4706 (2013.01); G01N 2800/164 (2013.01)] | 33 Claims |
1. A method for preventing or reducing proliferation or migration of retinal pigment epithelial (RPE) cells in a subject who has not been diagnosed with aberrant angiogenesis or small vessel disease and who comprises a retinal hole or retinal tear, the method comprising administering to the subject a composition comprising a small molecule selected from the group consisting of:
a small molecule comprising the structure of Formula I:
or a pharmaceutically acceptable salt or ester thereof, wherein
each R1 is individually selected from halogen, alkyl, aryl, heteroaryl, or alkoxy,
and R1 is selected from aryl or heteroaryl, and
a is 0 to 4; or
a small molecule comprising the structure of Formula III:
or a pharmaceutically acceptable salt or ester thereof, wherein
each R1 is individually selected from halogen, alkyl, aryl, heteroaryl, or alkoxy,
R2 is selected from aryl or heteroaryl;
R3 is alkyl or aryl, and
a is 0 to 4; or
a small molecule comprising the structure of Formula V:
or a pharmaceutically acceptable salt or ester thereof, wherein
R1 is H3, NH2, or NHC(O)CH3, and
X is CH2 or C(O).
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