US 11,739,217 B2
Engineered skin equivalent, method of manufacture thereof and products derived therefrom
Ingvar Helgason, South San Francisco, CA (US); and Dusko Ilic, London (GB)
Assigned to VitroLabs Inc, Milpitas, CA (US); and King's College London, London (GB)
Filed by VitroLabs Inc, Milpitas, CA (US); and King's College London, London (GB)
Filed on Jan. 3, 2023, as Appl. No. 18/92,816.
Application 18/092,816 is a continuation of application No. 17/751,440, filed on May 23, 2022, granted, now 11,591,471.
Application 17/751,440 is a continuation of application No. 17/366,550, filed on Jul. 2, 2021, granted, now 11,377,559, issued on Jul. 5, 2022.
Application 17/366,550 is a continuation of application No. 16/892,839, filed on Jun. 4, 2020, granted, now 11,091,639, issued on Aug. 17, 2021.
Application 16/892,839 is a continuation of application No. 16/299,734, filed on Mar. 12, 2019, granted, now 10,711,136, issued on Jul. 14, 2020.
Application 16/299,734 is a continuation of application No. 15/493,083, filed on Apr. 20, 2017, granted, now 10,273,549, issued on Apr. 30, 2019.
Claims priority of provisional application 62/325,819, filed on Apr. 21, 2016.
Prior Publication US 2023/0159758 A1, May 25, 2023
Int. Cl. C14C 3/02 (2006.01); C08L 89/06 (2006.01); C12N 5/071 (2010.01); C12N 11/02 (2006.01); C14C 13/00 (2006.01)
CPC C08L 89/06 (2013.01) [C12N 5/0625 (2013.01); C12N 5/0629 (2013.01); C12N 5/0698 (2013.01); C12N 11/02 (2013.01); C14C 3/02 (2013.01); C14C 13/00 (2013.01); C12N 2501/155 (2013.01); C12N 2501/385 (2013.01); C12N 2502/091 (2013.01); C12N 2502/094 (2013.01); C12N 2502/13 (2013.01); C12N 2506/45 (2013.01); C12N 2533/30 (2013.01); C12N 2533/54 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of forming a tanned synthetic leather, wherein the method comprises:
a) forming an artificial dermal layer comprising a fibroblast on a scaffold, wherein the scaffold comprises cellulose or a modified version thereof;
b) processing the artificial dermal layer to provide an extracellular matrix; and
c) tanning at least a portion of the extracellular matrix to generate the tanned synthetic leather.