CPC C07K 16/2827 (2013.01) [C07K 16/468 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/55 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01)] | 18 Claims |
1. A bispecific antibody in the form of a heterodimer consisting of a first antibody, which comprises a first Fc chain and a first antigen-binding functional region that can specifically bind to human PD-L1; and a second antibody which comprises a second Fc chain and a second antigen-binding functional region that can specifically bind to human CD47;
wherein the first antibody comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO.: 2, a light chain constant region comprising the amino acid sequence of SEQ ID NO.: 4, a heavy chain variable region comprising the amino acid sequence of SEQ ID NO.: 6 and a heavy chain constant region comprising the amino acid sequence of SEQ ID NO.: 8; and
wherein the second antibody comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO.: 10, a light chain constant region comprising the amino acid sequence of SEQ ID NO.: 4, a heavy chain variable region comprising the amino acid sequence of SEQ ID NO.: 12 and a heavy chain constant region comprising the amino acid sequence of SEQ ID NO.: 14.
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