CPC C07K 14/55 (2013.01) [C07K 14/57 (2013.01); C07K 14/7155 (2013.01); C07K 16/2887 (2013.01); A61K 47/642 (2017.08); A61K 2039/505 (2013.01); C07K 14/52 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C07K 2319/33 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01)] | 16 Claims |
1. A recombinant pro-protein comprising:
a. a recombinant polypeptide comprising, a cleavable moiety that is a substrate for a protease, wherein the cleavable moiety comprises the amino acid sequence of SEQ ID NO: 198 or a functional variant of SEQ ID NO: 198 in which one or two amino acids are substituted in SEQ ID NO: 198; and
b. a polypeptide with biological activity.
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