CPC C07D 261/10 (2013.01) [A61K 31/42 (2013.01); A61K 31/44 (2013.01); C07C 13/04 (2013.01); C07C 25/13 (2013.01); C07C 39/28 (2013.01); C07D 205/02 (2013.01); C07D 401/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)] | 17 Claims |
1. A method of treating a patient suffering from Primary Biliary Cirrhosis (PBC) or Primary Sclerosing Cholangitis (PSC) comprising administering to the patient a compound having the structure of Formula (Ia):
wherein:
Q is phenylene substituted with one chloro;
Y is N;
R1 is cyclopropyl or methyl;
R2 and R3 are chloro;
R4-A is:
wherein the pyridylene is optionally substituted with one or two groups independently selected from halogen, C1-4-alkoxy, halo-C1-4-alkoxy, C1-4-alkyl, and halo-C1-4-alkyl, and R4 is —CO2R5 or —C(O)NR5R6;
R5 is hydrogen; and
R6 is C1-2-alkyl optionally substituted with —CO2H or —SO3H;
or a pharmaceutically acceptable salt, a stereoisomer, a mixture of stereoisomers, or a tautomer thereof.
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