US 11,739,050 B2
Method for purification of terpenoid amino alcohol derivatives
Chen-Yi Kao, Taoyuan (TW); and Feng-Hsu Li, Taoyuan (TW)
Assigned to SCI PHARMTECH INC., Taoyuan (TW)
Filed by SCI PHARMTECH INC., Taoyuan (TW)
Filed on Sep. 7, 2021, as Appl. No. 17/467,974.
Prior Publication US 2023/0103071 A1, Mar. 30, 2023
Int. Cl. C07C 213/10 (2006.01); C07C 213/02 (2006.01); C07D 301/03 (2006.01)
CPC C07C 213/10 (2013.01) [C07C 213/02 (2013.01); C07D 301/03 (2013.01); C07C 2601/14 (2017.05)] 20 Claims
 
1. A method of purifying a terpenoid amino alcohol derivative represented by formula V′, comprising:
providing a crude terpenoid amino alcohol derivative represented by formula V′ below:

OG Complex Work Unit Chemistry
performing an acid/base crystallization process of the crude terpenoid amino alcohol derivative represented by formula V′ to obtain an organic salt represented by formula V″ below:

OG Complex Work Unit Chemistry
and
reacting the organic salt represented by formula V″ with at least one solvent selected from NaOH, toluene, cyclopentyl methyl ether, diethyl ether, and dimethoxyethane to obtain a purified terpenoid amino alcohol derivative represented by formula V′,
wherein R, R1, and R2 are independently a substituted or unsubstituted C1-C6 alkyl.