CPC C07C 69/753 (2013.01) [C07C 61/04 (2013.01); C07C 69/757 (2013.01); C07C 205/55 (2013.01); C07C 233/25 (2013.01); C07D 215/06 (2013.01); C07D 249/06 (2013.01); C07D 309/06 (2013.01); C07C 2601/04 (2017.05); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05); C07C 2602/10 (2017.05); C07C 2603/18 (2017.05)] | 20 Claims |
1. A method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound having the structure:
wherein
one of R1 or R2 is —C(═O)OH and the other of R1 or R2 is —C(═O)OR13 or —C(═O)O-alkyl-R14,
wherein
R13 is cycloalkyl, aryl or heteroaryl, and
R14 is CF3, cycloalkyl, cycloheteroalkyl, aryl or heteroaryl; and
R3, R4, R5, R6, Ry, R8, R9, R10, R11 and R12 are each independently, H—OR15 or halogen
wherein R15 is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, or heteroaryl,
wherein when one of R1 or R2 is —C(═O)OH and R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each H, then the other of R1 or R2 is other than —C(═O)OR13 where R13 is 1-naphthyl or 2-naphthyl or —C(═O)O-alkyl-R14 where the alkyl is a branched C2 alkyl and the R14 is phenyl,
or an enantiomer or racemate thereof;
or a pharmaceutically acceptable salt thereof.
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