US 11,738,199 B2
Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction
Bruce H. KenKnight, Maple Grove, MN (US); Jeffrey L. Ardell, Johnson City, TN (US); Imad Libbus, St. Paul, MN (US); and Badri Amurthur, Los Gatos, CA (US)
Assigned to LivaNova USA, Inc., Houston, TX (US); and East Tennessee State University, Johnson City, TN (US)
Filed by LivaNova USA, Inc., Houston, TX (US); and EAST TENNESSEE STATE UNIVERSITY, Johnson City, TN (US)
Filed on Jul. 30, 2021, as Appl. No. 17/390,481.
Application 17/390,481 is a continuation of application No. 16/422,588, filed on May 24, 2019, granted, now 11,077,304.
Application 16/422,588 is a continuation of application No. 15/600,519, filed on May 19, 2017, granted, now 10,300,284.
Application 15/600,519 is a continuation of application No. 15/230,023, filed on Aug. 5, 2016, granted, now 9,669,220.
Application 15/230,023 is a continuation of application No. 14/224,922, filed on Mar. 25, 2014, granted, now 9,409,024.
Prior Publication US 2022/0016429 A1, Jan. 20, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01)
CPC A61N 1/36139 (2013.01) [A61N 1/3615 (2013.01); A61N 1/36053 (2013.01); A61N 1/36114 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of operating an implantable medical device (IMD), the method comprising:
generating a plurality of stimulation signals configured to stimulate a nerve of a patient, each stimulation signal of the plurality of stimulation signals having a duty cycle, a frequency, an amplitude, and a pulse width, wherein generating the plurality of stimulation signals comprises adjusting at least one of the duty cycle, the amplitude, or the pulse width while maintaining a fixed frequency across the plurality of stimulation signals;
detecting a cardiac parameter response of the patient during the generation of the plurality of stimulation signals;
identifying a range of the adjusted at least one of the duty cycle, the pulse width, or the amplitude that results in the cardiac parameter response being between a baseline cardiac parameter and a cardiac parameter decrease threshold; and
delivering a plurality of stimulation signals at a duty cycle, a frequency, an amplitude, and a pulse width resulting in the cardiac parameter response being between the baseline cardiac parameter and the cardiac parameter decrease threshold.