US 11,738,161 B2
System and method for adaptive scheduling of pause maneuvers used for estimation of compliance and/or resistance during mechanical ventilation
Antonio Albanese, Mission Viejo, CA (US); Francesco Vicario, Boston, MA (US); Caitlyn Marie Chiofolo, New Hyde Park, NY (US); Nicolas Wadih Chbat, White Plains, NY (US); Fernando Jose Isaza, Carlsbad, CA (US); Smita Garde, Irvine, CA (US); Daniel Van Hise, Dover, NH (US); and Adam Jacob Seiver, Los Altos Hills, CA (US)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Appl. No. 16/478,022
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Jan. 12, 2018, PCT No. PCT/EP2018/050774
§ 371(c)(1), (2) Date Jul. 15, 2019,
PCT Pub. No. WO2018/130658, PCT Pub. Date Jul. 19, 2018.
Claims priority of provisional application 62/446,644, filed on Jan. 16, 2017.
Prior Publication US 2020/0121877 A1, Apr. 23, 2020
Int. Cl. A61M 16/00 (2006.01); A61M 15/00 (2006.01); A61M 16/20 (2006.01); G06F 17/18 (2006.01)
CPC A61M 16/024 (2017.08) [A61M 15/002 (2014.02); A61M 16/0003 (2014.02); A61M 16/202 (2014.02); G06F 17/18 (2013.01); A61M 2016/0027 (2013.01); A61M 2016/0033 (2013.01); A61M 2205/3327 (2013.01); A61M 2205/3334 (2013.01); A61M 2230/46 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A ventilation device comprising:
a mechanical ventilator;
respiratory sensors configured to acquire measurements of respiratory variables including at least measurements of airway pressure and airway flow;
an electronic processor; and
a non-transitory storage medium storing instructions readable and executable by the electronic processor to perform a ventilation method including:
operating the mechanical ventilator to provide mechanical ventilation controlled using measurements acquired by the respiratory sensors,
performing a pause maneuver comprising closing at least one of an inhalation valve and an exhalation valve for a pause interval;
estimating a respiratory mechanics index from one or more respiratory system parameters estimated from measurements acquired by the respiratory sensors during or after the pause interval including estimating the respiratory mechanics index by computing a time constant (τ) of a decay or airway flow measured by the respiratory sensors during an exhalation phase of a breath,
detecting a change in the estimated respiratory mechanics index including detecting the change in the estimated respiratory mechanics index as a detected change in the time constant computed over successive breaths, and
triggering a second pause maneuver in response to the detected change in the estimated respiratory mechanics index including:
triggering the pause maneuver in response to the detected change in the time constant over successive breaths exceeding a threshold indicative of the detected change in the estimated respiratory mechanics index; and
storing the computed time constant as an updated threshold when the detected change in the time constant over successive breaths underruns the threshold.