US 11,738,095 B2
Cyanine-containing compounds for cancer imaging and treatment
Leland W. K. Chung, Beverly Hills, CA (US); Lucjan Strekowski, Stone Mountain, GA (US); Chunmeng Shi, Chongqing (CN); Maged Henary, Lawrenceville, GA (US); Gabor Patonay, Conyers, GA (US); James J. Krutak, Colorado Springs, CO (US); Xiaojian Yang, Shannxi (CN); Guodong Zhu, Atlanta, GA (US); Ruoxiang Wang, Los Angeles, CA (US); and Haiyen E. Zhau, Beverly Hills, CA (US)
Assigned to Emory University, Atlanta, GA (US)
Filed by Emory University, Atlanta, GA (US); and Georgia State University Research Foundation, Inc., Atlanta, GA (US)
Filed on Feb. 2, 2017, as Appl. No. 15/422,948.
Application 15/422,948 is a continuation of application No. 14/815,591, filed on Jul. 31, 2015, abandoned.
Application 14/815,591 is a continuation of application No. 14/656,173, filed on Mar. 12, 2015, abandoned.
Application 14/656,173 is a continuation of application No. 12/668,460, abandoned, previously published as PCT/US2008/069631, filed on Jul. 10, 2008.
Claims priority of provisional application 60/959,413, filed on Jul. 13, 2007.
Prior Publication US 2017/0354747 A1, Dec. 14, 2017
Int. Cl. A61K 49/00 (2006.01); A61K 31/404 (2006.01); G01N 33/50 (2006.01); C07D 209/60 (2006.01); C07D 209/92 (2006.01); C07D 209/10 (2006.01)
CPC A61K 49/00 (2013.01) [A61K 31/404 (2013.01); C07D 209/10 (2013.01); C07D 209/60 (2013.01); C07D 209/92 (2013.01); G01N 33/5008 (2013.01)] 22 Claims
 
1. A method of imaging cancer cells, wherein the method comprises introducing to the cancer cells an imaging amount of a compound of the formula shown below

OG Complex Work Unit Chemistry
wherein each of R5 is H; and
wherein the R substituents are the same, or are not the same; and
wherein the R substituents are independently selected from the group consisting of: (CH2)3COOH, or an ester or amide thereof, (CH2)4COOH, or an ester or amide thereof, (CH2)5COOH, or an ester or amide thereof, (CH2)6COOH, or an ester or amide thereof, (CH2)7COOH, or an ester or amide thereof, (CH2)8COOH, or an ester or amide thereof, (CH2)9COOH, or an ester or amide thereof, (CH2)3SO3H, (CH2)4SO3H, (CH2)5SO3H, (CH2)6SO3H, (CH2)7SO3H, (CH2)8SO3H, and CH2)9SO3H;
exposing the cancer cells to electromagnetic radiation; and
detecting light emission from the compound; and
wherein the compound is introduced to one or more cancer cells without a targeting agent; and
wherein the amide of the R substituent is not tagged with a radioactive group; and
wherein if the compound is used in combination with a therapeutic agent or radioactive agent, the agent is co-administered with the compound simultaneously or sequentially, and is not linked to the compound.