CPC A61K 49/00 (2013.01) [A61K 31/404 (2013.01); C07D 209/10 (2013.01); C07D 209/60 (2013.01); C07D 209/92 (2013.01); G01N 33/5008 (2013.01)] | 22 Claims |
1. A method of imaging cancer cells, wherein the method comprises introducing to the cancer cells an imaging amount of a compound of the formula shown below
wherein each of R5 is H; and
wherein the R substituents are the same, or are not the same; and
wherein the R substituents are independently selected from the group consisting of: (CH2)3COOH, or an ester or amide thereof, (CH2)4COOH, or an ester or amide thereof, (CH2)5COOH, or an ester or amide thereof, (CH2)6COOH, or an ester or amide thereof, (CH2)7COOH, or an ester or amide thereof, (CH2)8COOH, or an ester or amide thereof, (CH2)9COOH, or an ester or amide thereof, (CH2)3SO3H, (CH2)4SO3H, (CH2)5SO3H, (CH2)6SO3H, (CH2)7SO3H, (CH2)8SO3H, and CH2)9SO3H;
exposing the cancer cells to electromagnetic radiation; and
detecting light emission from the compound; and
wherein the compound is introduced to one or more cancer cells without a targeting agent; and
wherein the amide of the R substituent is not tagged with a radioactive group; and
wherein if the compound is used in combination with a therapeutic agent or radioactive agent, the agent is co-administered with the compound simultaneously or sequentially, and is not linked to the compound.
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