US 11,738,094 B2
Intrathecal delivery of recombinant adeno-associated virus 9
Brian K. Kaspar, Westerville, OH (US); Arthur H. M. Burghes, Columbus, OH (US); and Paul N. Porensky, Columbus, OH (US)
Assigned to NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US); and OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
Filed by NATIONWIDE CHILDREN'S HOSPITAL, Columbus, OH (US); and OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
Filed on May 8, 2019, as Appl. No. 16/406,895.
Application 16/406,895 is a continuation of application No. 16/247,420, filed on Jan. 14, 2019.
Application 16/247,420 is a continuation of application No. 16/129,096, filed on Sep. 12, 2018, abandoned.
Application 16/129,096 is a continuation of application No. 15/863,429, filed on Jan. 5, 2018, abandoned.
Application 15/863,429 is a continuation of application No. 15/488,203, filed on Apr. 14, 2017, abandoned.
Application 15/488,203 is a continuation of application No. 14/417,823, abandoned, previously published as PCT/US2013/053065, filed on Jul. 31, 2013.
Claims priority of provisional application 61/678,458, filed on Aug. 1, 2012.
Prior Publication US 2019/0262474 A1, Aug. 29, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 48/00 (2006.01); A61K 49/04 (2006.01); C12N 15/86 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C07H 21/04 (2006.01)
CPC A61K 48/0075 (2013.01) [A61K 38/1709 (2013.01); A61K 48/0008 (2013.01); A61K 49/0438 (2013.01); C07K 14/47 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C07H 21/04 (2013.01); C12N 2750/14143 (2013.01)] 5 Claims
 
1. A composition formulated for intrathecal administration to the spinal cord, wherein the composition comprises: (a) a recombinant AAV9 (rAAV9) comprising an rAAV9 genome comprising a CLN6 gene; and (b) contrast agent.