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1. A recombinant glycosylated polypeptide comprising an amino acid sequence identical to a naturally-occurring human protein or fragment thereof, wherein said recombinant glycosylated polypeptide contains one or more clusters of O-glycosylation sites, wherein a cluster contains at least three O-glycosylation sites and at least one O-glycosylation site in four amino acids; wherein the total number of O-glycosylation sites and the combined number of sialylated core 2 and extended core 1 O-glycans of the recombinant glycosylated polypeptide is higher than the total number of O-glycosylation sites and the combined number of sialylated core 2 and extended core 1 O-glycans of the naturally-occurring human protein or fragment thereof; and wherein the recombinant glycosylated polypeptide shows an increased binding affinity to one or more SIGLECs selected from SIG-5, SIG-7, SIG-8, and SIG-9, compared to the naturally-occurring human protein or fragment thereof.
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