US 11,738,063 B2
Pharmaceutical composition for preventing or treating neurodegenerative diseases which includes flower extract of Daphne genkwa or fractions thereof as active ingredient
Won Gon Kim, Daejeon (KR); Baek Soo Han, Daejeon (KR); Jeong Su Byun, Daejeon (KR); and Ha Young Choi, Daejeon (KR)
Assigned to KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, Daejeon (KR)
Filed by KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, Daejeon (KR)
Filed on Sep. 4, 2020, as Appl. No. 17/12,238.
Application 17/012,238 is a division of application No. 16/349,762, granted, now 10,792,323, previously published as PCT/KR2017/012790, filed on Nov. 13, 2017.
Claims priority of application No. 10-2016-0150983 (KR), filed on Nov. 14, 2016.
Prior Publication US 2021/0106645 A1, Apr. 15, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 36/83 (2006.01); A61P 25/16 (2006.01)
CPC A61K 36/83 (2013.01) [A61P 25/16 (2018.01)] 6 Claims
 
1. A method of treating or ameliorating a neurodegenerative disease, comprising administering to a mammal in need thereof a composition comprising a therapeutically effective amount of an aqueous extract or lower-alkyl alcohol extract of flower or flower buds of Daphne genkwa or a fraction thereof, wherein the neurodegenerative disease is Parkinson's disease or frontotemporal dementia, and the therapeutically effective amount is 10 mg/kg to 100 mg/kg per day.