US 11,738,037 B2
Agent for preventing or improving decline in brain function
Kota Kumagai, Tsukuba (JP); Masahiko Morita, Tsukuba (JP); Takahiro Hara, Tsukuba (JP); and Kohji Fukunaga, Sendai (JP)
Assigned to KYOWA HAKKO BIO CO., LTD., Tokyo (JP)
Filed by KYOWA HAKKO BIO CO., LTD., Tokyo (JP)
Filed on Dec. 30, 2020, as Appl. No. 17/138,742.
Application 17/138,742 is a continuation of application No. 14/435,984, granted, now 10,905,705, previously published as PCT/JP2013/080053, filed on Oct. 30, 2013.
Claims priority of application No. 2012-238542 (JP), filed on Oct. 30, 2012.
Prior Publication US 2021/0113601 A1, Apr. 22, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/7068 (2006.01); A61K 31/198 (2006.01)
CPC A61K 31/7068 (2013.01) [A61K 31/198 (2013.01)] 18 Claims
 
1. A method of protecting brain neuronal cells comprising orally administering an effective amount of the combination of (a) citrulline or a salt thereof and (b) citicoline or a salt thereof to a human subject in need thereof, thereby protecting brain neuronal cells in the subject, wherein citrulline or a salt thereof and citicoline or a salt thereof are each orally administered at a dose of 100-300 mg/day.