US 11,737,723 B2
Multi-modal ultrasound probe for calibration-free cuff-less evaluation of blood pressure
Nabeel Pilaparambil Mashood, Chennai (IN); Jayaraj Joseph, Chennai (IN); Mohanasankar Sivaprakasam, Chennai (IN); and Vangapandu Raj Kiran, Chennai (IN)
Assigned to HEALTHCARE TECHNOLOGY INNOVATION CENTER, Chennai (IN)
Appl. No. 16/765,836
Filed by Healthcare Technology Innovation Centre, Chennai (IN)
PCT Filed Jun. 7, 2019, PCT No. PCT/IN2019/050438
§ 371(c)(1), (2) Date May 20, 2020,
PCT Pub. No. WO2019/234764, PCT Pub. Date Dec. 12, 2019.
Claims priority of application No. 201841021390 (IN), filed on Jun. 7, 2018; and application No. PCT/IN2019/050438 (WO), filed on Jun. 7, 2019.
Prior Publication US 2021/0093287 A1, Apr. 1, 2021
Int. Cl. A61B 8/04 (2006.01); A61B 8/02 (2006.01); A61B 8/00 (2006.01); A61B 8/08 (2006.01); A61B 5/021 (2006.01); A61B 5/0295 (2006.01)
CPC A61B 8/04 (2013.01) [A61B 5/0295 (2013.01); A61B 5/02108 (2013.01); A61B 8/02 (2013.01); A61B 8/429 (2013.01); A61B 8/4236 (2013.01); A61B 8/5223 (2013.01); A61B 8/54 (2013.01); A61B 8/0891 (2013.01); A61B 2562/0219 (2013.01); A61B 2562/0247 (2013.01); A61B 2562/043 (2013.01)] 8 Claims
OG exemplary drawing
 
1. An arterial compliance probe for cuff-less measurement of blood pressure (BP) of a subject, the arterial compliance probe comprising:
a probe holder to apply the arterial compliance probe on a measurement site of the subject;
a first ultrasound transducer, connected at a first end of the probe holder, configured to measure a first arterial dimension waveform at a first fiducial point of the measurement site of the subject;
a second ultrasound transducer, connected to a second end of the probe holder, configured to measure a second arterial dimension waveform at a second fiducial point different than the first fiducial point of the measurement site of the subject,
wherein the first arterial dimension waveform and the second arterial dimension waveform are measured within a cardiac cycle; and
a controller, connected to the first ultrasound transducer and the second ultrasound transducer, configured to:
measure an arterial dimension parameter within the cardiac cycle from the first arterial dimension waveform and the second arterial dimension waveform,
measure a variation in a local pulse wave velocity within the cardiac cycle based on a time difference between the first arterial dimension waveform and the second arterial dimension waveform,
measure a stiffness property of an artery based on the variation in the local pulse wave velocity, and
measure the BP of the subject based on the variation in the local pulse wave velocity, the stiffness property, and the arterial dimension parameter.