| US 11,427,612 B2 | ||
| Epimerization-free N to C solid-phase peptide synthesis | ||
| Jennifer L. Stockdill, West Bloomfield Township, MI (US); and Christine A. Arbour, Cambridge, MA (US) | ||
| Assigned to Wayne State University, Detroit, MI (US) | ||
| Filed by Wayne State University, Detroit, MI (US) | ||
| Filed on Aug. 21, 2019, as Appl. No. 16/546,549. | ||
| Claims priority of provisional application 62/720,668, filed on Aug. 21, 2018. | ||
| Prior Publication US 2020/0062801 A1, Feb. 27, 2020 | ||
| Int. Cl. C07K 1/08 (2006.01); C07K 1/10 (2006.01); C07K 1/04 (2006.01); C07K 1/02 (2006.01) | ||
| CPC C07K 1/042 (2013.01) [C07K 1/023 (2013.01); C07K 1/084 (2013.01); C07K 1/10 (2013.01)] | 20 Claims |
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1. A method of synthesizing a peptide, wherein the method comprises preparing a first amino acid for synthesis, coupling an amino group of a second amino acid to the carboxyl group of the first amino acid to obtain a peptide, and optionally elongating the peptide by coupling one or more amino acids sequentially to a C-terminus of the peptide, wherein the amino acids used in the method are derivatized amino acids comprising a diamino-aryl group, and wherein the method proceeds without detectable epimerization of the second or sequentially coupled amino acid at the carboxyl terminus of the peptide.
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