US 11,427,612 B2
Epimerization-free N to C solid-phase peptide synthesis
Jennifer L. Stockdill, West Bloomfield Township, MI (US); and Christine A. Arbour, Cambridge, MA (US)
Assigned to Wayne State University, Detroit, MI (US)
Filed by Wayne State University, Detroit, MI (US)
Filed on Aug. 21, 2019, as Appl. No. 16/546,549.
Claims priority of provisional application 62/720,668, filed on Aug. 21, 2018.
Prior Publication US 2020/0062801 A1, Feb. 27, 2020
Int. Cl. C07K 1/08 (2006.01); C07K 1/10 (2006.01); C07K 1/04 (2006.01); C07K 1/02 (2006.01)
CPC C07K 1/042 (2013.01) [C07K 1/023 (2013.01); C07K 1/084 (2013.01); C07K 1/10 (2013.01)] 20 Claims
OG exemplary drawing
1. A method of synthesizing a peptide, wherein the method comprises preparing a first amino acid for synthesis, coupling an amino group of a second amino acid to the carboxyl group of the first amino acid to obtain a peptide, and optionally elongating the peptide by coupling one or more amino acids sequentially to a C-terminus of the peptide, wherein the amino acids used in the method are derivatized amino acids comprising a diamino-aryl group, and wherein the method proceeds without detectable epimerization of the second or sequentially coupled amino acid at the carboxyl terminus of the peptide.