US 12,069,383 B2
Hybrid visible and near infrared imaging with an RGB color filter array sensor
Michael Sowa, Calgary (CA); and Matt Cervi, Calgary (CA)
Assigned to Kent Imaging Inc., Calgary (CA)
Appl. No. 16/616,722
Filed by KENT IMAGING INC., Calgary (CA)
PCT Filed Sep. 12, 2018, PCT No. PCT/CA2018/051128
§ 371(c)(1), (2) Date Nov. 25, 2019,
PCT Pub. No. WO2019/051059, PCT Pub. Date Mar. 21, 2019.
Claims priority of provisional application 62/558,949, filed on Sep. 15, 2017.
Prior Publication US 2021/0075978 A1, Mar. 11, 2021
Int. Cl. H04N 25/131 (2023.01); A61B 5/026 (2006.01); H04N 23/11 (2023.01); H04N 23/84 (2023.01); H04N 25/11 (2023.01); H04N 25/133 (2023.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01)
CPC H04N 25/131 (2023.01) [A61B 5/0261 (2013.01); H04N 23/11 (2023.01); H04N 23/84 (2023.01); H04N 25/11 (2023.01); H04N 25/133 (2023.01); A61B 5/145 (2013.01); A61B 5/1455 (2013.01); H04N 2209/047 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for visible and/or near-infrared imaging of a sample of interest, comprising:
providing a color filter array sensor comprising a first channel and a second channel;
illuminating the sample of interest with a first illuminant source that emits at a first illuminant wavelength range, wherein the first illuminant wavelength range includes light of visible and/or near-infrared wavelengths;
measuring light intensity of the first illuminant wavelength range reflected by the sample into both the first channel and the second channel of the color filter array sensor to produce:
a first channel signal of the first illuminant wavelength range as output from the first channel of the color filter array sensor; and
a second channel signal of the first illuminant wavelength range as output from the second channel of the color filter array sensor;
generating one or more first illumination image frames indicating hemoglobin oxygen saturation by processing the first channel signal and the second channel signal of the first illuminant wavelength range, wherein processing the first channel signal and the second channel signal of the first illuminant wavelength range comprises mathematical unmixing to provide a signal at each wavelength of the first illuminant wavelength range, wherein the first illuminant wavelength range includes a plurality of wavelengths;
illuminating the sample of interest with a second illuminant source that emits a second illuminant wavelength range, wherein the second illuminant wavelength range includes light of visible and/or near-infrared wavelengths different from the light of visible and/or near-infrared wavelengths of the first illuminant wavelength range;
measuring light intensity of the second illuminant wavelength range reflected by the sample into both the first and second channels of the color filter array sensor to produce:
a first channel signal of the second illuminant wavelength range as output from the first channel of the color filter array sensor; and
a second channel signal of the second illuminant wavelength range as output from the second channel of the color filter array sensor;
generating one or more second illumination image frames indicating hemoglobin oxygen saturation by processing the first channel signal and the second channel signal of the second illuminant wavelength range; and
assembling the first illumination image frames and the second illumination image frames to generate at least one multispectral or hyperspectral image of the hemoglobin oxygen saturation of the sample of interest.