US 12,066,512 B2
Systems and methods for rapidly determining one or more metabolite measurements from MR spectroscopy data
Hyunsuk Shim, Atlanta, GA (US); Lee Cooper, Atlanta, GA (US); Saumya Gurbani, Atlanta, GA (US); Andrew Maudsley, Miami, FL (US); and Sulaiman Sheriff, Miami, FL (US)
Assigned to Emory University, Atlanta, GA (US); and University of Miami, Miami, FL (US)
Appl. No. 17/295,528
Filed by Emory University, Atlanta, GA (US); and University of Miami, Miami, FL (US)
PCT Filed Nov. 20, 2019, PCT No. PCT/US2019/062492
§ 371(c)(1), (2) Date May 20, 2021,
PCT Pub. No. WO2020/106896, PCT Pub. Date May 28, 2020.
Claims priority of provisional application 62/769,842, filed on Nov. 20, 2018.
Prior Publication US 2022/0018922 A1, Jan. 20, 2022
Int. Cl. G01R 33/485 (2006.01); G01R 33/46 (2006.01); G06N 3/045 (2023.01); G06N 3/084 (2023.01)
CPC G01R 33/485 (2013.01) [G01R 33/4625 (2013.01); G06N 3/045 (2023.01); G06N 3/084 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for determining a concentration of one or more metabolites within a region of interest comprising:
processing magnetic resonance (MR) spectroscopy data of a region of interest, the magnetic resonance spectroscopy data including a plurality of spectra of one or more metabolites, through a series of neural networks, the processing including:
determining baseline components of each spectrum using a first neural network of the series, the baseline components defining a baseline model;
generating baseline-corrected components for each spectrum using the baseline components; and
determining one or more peak components of each spectrum using a second neural network of the series and the baseline-corrected components; and
determining one or more metabolite measurements of the one or more metabolites in the region of interest using the one or more peak components.