US 12,065,696 B2
Systems and methods for genetic identification and analysis
Darrell Orlyn Ricke, Winchester, MA (US); James Harper, Jamaica Plain, MA (US); Brian S. Helfer, Brookline, MA (US); Joseph Isaacson, Latham, NY (US); Adam M. Michaleas, Hudson, NH (US); Martha S. Petrovick, Barre, MA (US); Eric Schwoebel, Woburn, MA (US); Anna Shcherbina, East Palo Alto, CA (US); Philip Fremont-Smith, Newmarket, NH (US); James G. Watkins, Sutton, MA (US); and Edward C. Wack, Waltham, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Feb. 1, 2023, as Appl. No. 18/104,727.
Application 18/104,727 is a continuation of application No. 16/629,081, granted, now 11,655,498, previously published as PCT/US2018/041081, filed on Jul. 6, 2018.
Claims priority of provisional application 62/534,590, filed on Jul. 19, 2017.
Claims priority of provisional application 62/529,939, filed on Jul. 7, 2017.
Prior Publication US 2023/0287487 A1, Sep. 14, 2023
Int. Cl. C12Q 1/68 (2018.01); C12Q 1/6858 (2018.01); C12Q 1/6869 (2018.01); C12Q 1/6886 (2018.01); G16B 20/00 (2019.01); G16B 40/10 (2019.01)
CPC C12Q 1/6858 (2013.01) [C12Q 1/6869 (2013.01); C12Q 1/6886 (2013.01); G16B 20/00 (2019.02); G16B 40/10 (2019.02); C12Q 2600/156 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A SNP panel comprising one, two, or more loci of a single-nucleotide polymorphism (SNP) having at least one of:
(a) a low fixation index (FST);
(b) a low minor allele frequency (mAF) value or a low average heterozygosity value; and
wherein a low mAF indicates that the minor allele is rare in a population.