CPC C07K 17/02 (2013.01) [C07K 16/18 (2013.01); G01N 33/577 (2013.01); G01N 33/6896 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); G01N 2800/2835 (2013.01)] | 3 Claims |
1. A monoclonal antibody having a binding domain that binds to a peptide of the Huntingtin (HTT) protein having the sequence of p7543 (SEQ ID No. 3) and
wherein the monoclonal antibody comprises a heavy chain variable region CDR1 comprising GYTFTEYT (SEQ ID No. 66), a heavy chain variable region CDR2 comprising INPNNGGT (SEQ ID No. 67), a heavy chain variable region CDR3 comprising ASLDGRDY (SEQ ID No. 68), a light chain variable region CDR1 comprising QSLLNSRTRKNY SEQ ID No. 69), a light chain variable region CDR2 comprising WASX (SEQ ID No. 70) and a light chain variable region comprising KQSYNLLT (SEQ ID No. 71); or
wherein the monoclonal antibody comprises a light chain variable region comprising SEQ ID NO:97 and a heavy chain variable region comprising SEQ ID NO:98.
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