	US 12,065,493 B2
	Anti-MICA/B antibodies that block MICA/B shedding and methods of use
Neil Gibson, Cambridge, MA (US); Justin Chapman, Cambridge, MA (US); and Xin Du, Cambridge, CA (US)
Assigned to Cullinan Mica Corporation, Cambridge, MA (US)
Filed by Cullinan Mica Corporation, Cambridge, MA (US)
Filed on Jan. 29, 2021, as Appl. No. 17/162,585.
Application 17/162,585 is a continuation of application No. PCT/US2019/044234, filed on Jul. 30, 2019.
Claims priority of provisional application 62/712,608, filed on Jul. 31, 2018.
Prior Publication US 2021/0253711 A1, Aug. 19, 2021
Int. Cl. C07K 16/28 (2006.01)

CPC C07K 16/2833 (2013.01) [C07K 2317/24 (2013.01); C07K 2317/565 (2013.01)]

16 Claims

1. A monoclonal antibody or an antigen-binding fragment thereof, comprising, light chain complementarity determining regions (LCDR) 1-3 and heavy chain complementarity determining regions (HCDR) 1-3 as follows:

a. LCDR1 is SEQ ID NO: 1, LCDR2 is SEQ ID NO: 2, LCDR3 is SEQ ID NO: 3, HCDR1 is SEQ ID NO: 4, HCDR2 is SEQ ID NO: 5, and HCDR3 is SEQ ID NO: 6; or

b. LCDR1 is SEQ ID NO: 9, LCDR2 is SEQ ID NO: 10, LCDR3 is SEQ ID NO: 11, HCDR1 is SEQ ID NO: 12, HCDR2 is SEQ ID NO: 13, and HCDR3 is SEQ ID NO: 14; or

c. LCDR1 is SEQ ID NO: 17, LCDR2 is SEQ ID NO: 2, LCDR3 is SEQ ID NO: 3, HCDR1 is SEQ ID NO: 4, HCDR2 is SEQ ID NO: 18, and HCDR3 is SEQ ID NO: 6.