	US 12,065,475 B2
	T cell receptors and fusion proteins thereof
Paul Conroy, Abingdon (GB); Stephen Hearty, Abingdon (GB); and Lok Hang Mak, Abingdon (GB)
Assigned to Immunocore Ltd, Abingdon (GB)
Filed by Immunocore Ltd, Abingdon (GB)
Filed on Dec. 15, 2023, as Appl. No. 18/542,441.
Application 18/542,441 is a continuation of application No. 18/451,415, filed on Aug. 17, 2023.
Claims priority of provisional application 63/399,095, filed on Aug. 18, 2022.
Prior Publication US 2024/0109950 A1, Apr. 4, 2024
Int. Cl. A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 15/63 (2006.01)

CPC C07K 14/7051 (2013.01) [A61P 35/00 (2018.01); C12N 15/63 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/30 (2013.01)]

21 Claims

1. A T cell receptor (TCR) fusion protein comprising a TCR that binds to GVYDGREHTV (SEQ ID NO: 34) HLA-A*02 complex, wherein the TCR fusion protein comprises a first polypeptide comprising the amino acid sequence of SEQ ID NO:29, a second polypeptide comprising the amino acid sequence of SEQ ID NO:30, and a third polypeptide comprising the amino acid sequence of SEQ ID NO:28.