CPC C07K 14/7051 (2013.01) [A61K 39/001111 (2018.08); A61P 35/02 (2018.01); C07K 14/70521 (2013.01); C07K 16/2803 (2013.01); C07K 16/2809 (2013.01); C07K 16/2818 (2013.01); C12N 15/62 (2013.01); C07K 2319/33 (2013.01); C12N 2510/00 (2013.01)] | 10 Claims |
1. A chimeric antigen receptor (CAR) polypeptide, comprising a co-stimulatory signaling region, wherein the co-stimulatory signaling region comprises a mutated form of a cytoplasmic domain of CD28 having at least one null mutation in a YMNM (SEQ ID NO:1) subdomain, and at least one null mutation in a PRRP (SEQ ID NO:2) subdomain but not having a null mutation in a PYAP (SEQ ID NO:3) subdomain.
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