CPC C07D 261/04 (2013.01) | 6 Claims |
1. A process for the preparation of fluralaner, the process comprising:
(a) reacting a compound of Formula (VI) with a compound of Formula (VII),
to obtain a compound of Formula (V),
wherein M is Cs,
wherein the reaction is performed in the presence of cesium carbonate;
(b) converting the compound of Formula (V) into a compound of Formula (IV) or its reactive derivative,
wherein the reaction is performed in the presence of boron trifluoride etherate and acetic anhydride;
(c) reacting the compound of Formula (IV) or its reactive derivative with 2-Amino-N-(2,2,2-trifluoroethyl)acetamide, or salts thereof to obtain a compound of Formula (II); and
(d) reacting the compound of Formula (II) with hydroxylamine, or salts thereof to obtain fluralaner.
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