US 12,065,392 B2
Root exudate-activated system for agrochemical delivery
Juan Schneider, Laval (CA); Carlos Monreal, Ottawa (CA); Maria Derosa, Ottawa (CA); Phillip Choi, Edmonton (CA); Emily Mastronardi, Ottawa (CA); Phepafatso Tsae, Ottawa (CA); and Francisco Matus, Temuco (CL)
Assigned to Carleton University, Ontario (CA); Her Majesty the Queen in Right of Canada, as represented by The Minister of Agriculture and Agri-Food, Ontario (CA); and The Governors of the University of Alberta, Alberta (CA)
Appl. No. 17/276,302
Filed by Carleton University, Ottawa (CA); Her Majesty the Queen in Right of Canada, as represented by The Minister of Agriculture and Agri-Food, Ottawa (CA); The Governors of the University of Alberta, Edmonton (CA); and Juan Schneider, Laval (CA)
PCT Filed Sep. 16, 2019, PCT No. PCT/CA2019/051306
§ 371(c)(1), (2) Date Mar. 15, 2021,
PCT Pub. No. WO2020/051717, PCT Pub. Date Mar. 19, 2020.
Claims priority of provisional application 62/731,454, filed on Sep. 14, 2018.
Prior Publication US 2022/0033322 A1, Feb. 3, 2022
Int. Cl. C05G 5/30 (2020.01); A01G 29/00 (2006.01); C05C 9/00 (2006.01); C09D 101/08 (2006.01); C12N 15/115 (2010.01); A01G 22/00 (2018.01)
CPC C05G 5/37 (2020.02) [A01G 29/00 (2013.01); C05C 9/005 (2013.01); C12N 15/115 (2013.01); A01G 22/00 (2018.02); C12N 2310/16 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A delivery system for delivering an agrochemical to a root of a plant, the system comprising particles configured to release the agrochemical, the particles comprising a coating, wherein the coating comprises an aptamer configured to bind specifically to a root exudate, wherein the root exudate comprises L-serine,
and wherein exposure of the particles to the root exudate results in an increase in permeability of the coating, so as to increase a rate of release of the agrochemical from the particles.
 
11. A method of preparing the delivery system of claim 1, the method comprising coating the particles with the coating.
 
12. An aptamer configured to bind specifically to a root exudate, wherein the root exudate comprises L-serine and wherein the aptamer has a sequence selected from the group consisting of SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34.
 
13. A coating for particles of an agrochemical, the coating comprising a cellulose derivative and an aptamer configured to bind specifically to a root exudate, wherein the root exudate comprises L-serine.