US 12,064,771 B2
Rapid sample temperature changing for assaying
Stephen Y. Chou, Princeton, NJ (US); Wei Ding, Princeton, NJ (US); and Hua Tan, Princeton Junction, NJ (US)
Assigned to Essenlix Corporation, Monmouth Junction, NJ (US)
Appl. No. 16/616,680
Filed by Essenlix Corporation, Monmouth Junction, NJ (US)
PCT Filed May 23, 2018, PCT No. PCT/US2018/034230
§ 371(c)(1), (2) Date Nov. 25, 2019,
PCT Pub. No. WO2018/217953, PCT Pub. Date Nov. 29, 2018.
Application 16/616,680 is a continuation of application No. PCT/US2018/028784, filed on Apr. 23, 2018.
Application 16/616,680 is a continuation of application No. PCT/US2018/018405, filed on Feb. 15, 2018.
Application 16/616,680 is a continuation of application No. PCT/US2018/018108, filed on Feb. 14, 2018.
Application 16/616,680 is a continuation of application No. PCT/US2018/017307, filed on Feb. 7, 2018.
Claims priority of provisional application 62/510,063, filed on May 23, 2017.
Prior Publication US 2020/0086325 A1, Mar. 19, 2020
Int. Cl. B01L 3/00 (2006.01); B01L 7/00 (2006.01)
CPC B01L 7/52 (2013.01) [B01L 3/5088 (2013.01); B01L 2300/1811 (2013.01); B01L 2300/1822 (2013.01); B01L 2300/1827 (2013.01)] 81 Claims
OG exemplary drawing
 
1. A device, comprising:
a first plate comprising a polymer or glass material and having a thickness less than or equal to 100 μm;
a second plate comprising a polymer or glass material and having a thickness less than or equal to 100 μm; wherein each of the first and second plates has a sample contact area for contacting a sample;
spacers; and
a heating/cooling layer disposed, on the sample contact area of one of the first and the second plates, the heating/cooling layer having a thermal conductivity, wherein the thermal conductivity times a thickness of the heating/cooling layer is between 6×10−5 and 1.5×10−4 W/K,
wherein the thickness of the heating/cooling layer is 15 μm or less and has a surface thermal radiation capability at least 50% of that of a blackbody; and
wherein the first plate and the second plate are configured to receive a fluid sample sandwiched between the first plate and the second plate; and
wherein the spacers regulate the spacing between the first plate and the second plate, at least one of the spacers is inside of one of the sample contact areas, and a fourth power of an inter-spacer-distance (ISD) of the spacers divided by the thickness (h) and a Young's modulus (E) of one of the first and second plates (ISD4/(hE)) is 5×106 μm3/GPa or less.