US 12,064,630 B2
Systems and methods for monitoring neural activity
Nicholas Sinclair, East Melbourne (AU); Hugh McDermott, East Melbourne (AU); Kristian Bulluss, East Melbourne (AU); Arthur Wesley Thevathasan, East Melbourne (AU); and Joel Villalobos, East Melbourne (AU)
Assigned to DEEP BRAIN STIMULATION TECHNOLOGIES PTY. LTD., East Melbourne (AU)
Appl. No. 17/052,683
Filed by DEEP BRAIN STIMULATION TECHNOLOGIES PTY LTD, East Melbourne (AU)
PCT Filed May 3, 2019, PCT No. PCT/AU2019/050407
§ 371(c)(1), (2) Date Nov. 3, 2020,
PCT Pub. No. WO2019/210371, PCT Pub. Date Nov. 7, 2019.
Claims priority of application No. 2018901516 (AU), filed on May 3, 2018.
Prior Publication US 2021/0236821 A1, Aug. 5, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61K 31/02 (2006.01); A61K 31/05 (2006.01); A61K 31/08 (2006.01); A61K 31/135 (2006.01); A61K 31/4174 (2006.01); A61K 31/4468 (2006.01); A61K 31/515 (2006.01); A61K 31/5513 (2006.01); A61K 33/00 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36139 (2013.01) [A61K 31/02 (2013.01); A61K 31/05 (2013.01); A61K 31/08 (2013.01); A61K 31/135 (2013.01); A61K 31/4174 (2013.01); A61K 31/4468 (2013.01); A61K 31/515 (2013.01); A61K 31/5513 (2013.01); A61K 33/00 (2013.01); A61N 1/0534 (2013.01); A61N 1/36171 (2013.01); A61N 1/36178 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A method of monitoring neural activity responsive to a stimulus in a brain of a subject, the method comprising:
a. inducing general anaesthesia in the subject;
b. applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain;
c. detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain;
d. determining one or more waveform characteristics of the detected resonant response, wherein the one or more waveform characteristics comprises a time elapsed between two peaks of the detected resonant response; and
e. determining whether one or more of the at least one electrode is positioned in the target neural structure based on the one or more waveform characteristics including the time elapsed between two peaks of the detected resonant response.