US 12,064,577 B2
Drug-coated balloon
Richard E. Kaufman, Los Gatos, CA (US); John Joseph Stankus, San Jose, CA (US); and James Su, Newark, CA (US)
Assigned to Intersect ENT, Inc., Menlo Park, CA (US)
Filed by Intersect ENT, Inc., Menlo Park, CA (US)
Filed on Aug. 28, 2020, as Appl. No. 17/005,868.
Application 17/005,868 is a continuation of application No. 16/790,464, filed on Feb. 13, 2020, granted, now 10,814,108.
Application 16/790,464 is a continuation of application No. 16/523,836, filed on Jul. 26, 2019, granted, now 10,603,473, issued on Mar. 31, 2020.
Application 16/523,836 is a continuation of application No. 15/004,807, filed on Jan. 22, 2016, granted, now 10,441,757, issued on Oct. 15, 2019.
Claims priority of provisional application 62/106,692, filed on Jan. 22, 2015.
Prior Publication US 2020/0391013 A1, Dec. 17, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 25/10 (2013.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61M 29/02 (2006.01)
CPC A61M 25/10 (2013.01) [A61L 29/085 (2013.01); A61L 29/16 (2013.01); A61M 29/02 (2013.01); A61L 2300/222 (2013.01); A61M 2025/105 (2013.01); A61M 2210/065 (2013.01); A61M 2210/0662 (2013.01); A61M 2210/0668 (2013.01); A61M 2210/0675 (2013.01); A61M 2210/0681 (2013.01); A61M 2210/105 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method, comprising:
providing an expandable device having a low-profile configuration, an expanded configuration, and an external surface;
priming the external surface of the expandable device with a hydrophilic excipient, a hydrophobic excipient, an amphiphilic excipient, a lipophilic excipient, or a combination thereof; and
applying a drug coating to the external surface of the expandable device, the drug coating comprising a mixture of crystalline and amorphous forms of a drug, where the drug coating comprises at least one of a local anesthetic, painkiller, vasoconstrictor, antiseptic, antioxidant, anti-inflammatory agent, anti-allergen agent, antibacterial agent, anti-cholinergic agent, antihistamine, anti-infective agent, anti-platelet agent, anti-coagulant, anti-thrombotic agent, anti-scarring agent, anti-proliferative agent, chemotherapeutic agent, anti-neoplastic agent, decongestant, healing promoting agent, vitamin, hypersomolar agent, immunomodulator, immunosuppressive agent, penetration enhancer, mucoadhesive, mucolytic, or combination thereof.