	US 12,064,534 B2
	Zwitterionic hydrogels for delivery of biomolecules
Jie Song, Shrewsbury, MA (US); and Pingsheng Liu, Worcester, MA (US)
Assigned to University of Massachusetts, Boston, MA (US)
Filed by University of Massachusetts, Boston, MA (US)
Filed on Mar. 16, 2022, as Appl. No. 17/695,964.
Application 17/695,964 is a continuation of application No. 16/598,024, filed on Oct. 10, 2019, granted, now 11,311,652.
Application 16/598,024 is a continuation of application No. 15/321,542, abandoned, previously published as PCT/US2015/039227, filed on Jul. 6, 2015.
Claims priority of provisional application 62/022,187, filed on Jul. 8, 2014.
Prior Publication US 2022/0288279 A1, Sep. 15, 2022
Int. Cl. A61L 27/44 (2006.01); A61K 38/18 (2006.01); A61K 38/30 (2006.01); A61L 27/14 (2006.01); A61L 27/18 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01)

CPC A61L 27/58 (2013.01) [A61K 38/18 (2013.01); A61K 38/1875 (2013.01); A61K 38/30 (2013.01); A61L 27/14 (2013.01); A61L 27/18 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 2300/414 (2013.01); A61L 2430/02 (2013.01)]

10 Claims

1. An implant consisting of a crosslinked 3-dimensioanl zwitterionic polymer and a protein, wherein the protein is encapsulated in the crosslinked 3-dimensional zwitterionic polymer and is characterized by preserved bioactivity as sequestered, wherein the crosslinked 3-dimensional zwitterionic polymer is polymethacrylate, polyacrylate, polymethacrylamide, or polyacrylamide crosslinked with poly (ethylene glycol) dimethacrylate, poly(ethylene glycol) diacrylate, ethylene glycol diacrylate, or ethylene glycol dimethacrylate.