US 12,064,518 B2
Formulations and methods for contemporaneous stabilization of active proteins during spray drying and storage
Qiyong Peter Liu, Newton, MA (US); Junqing Cui, West Roxbury, MA (US); Rud Karly Lucien, Lynn, MA (US); Ryan Carney, Hudson, NH (US); Jihae Sohn, Brighton, MA (US); Michelle Arya, Medford, MA (US); and Abdul W. Khan, Lindenhurst, IL (US)
Assigned to Velico Medical, Inc., Beverly, MA (US)
Filed by Velico Medical Inc., Beverly, MA (US)
Filed on Oct. 22, 2021, as Appl. No. 17/508,904.
Application 17/508,904 is a continuation of application No. 17/337,306, filed on Jun. 2, 2021.
Application 17/337,306 is a continuation of application No. 15/383,201, filed on Dec. 19, 2016, granted, now 11,052,045, issued on Jul. 6, 2021.
Application 15/383,201 is a continuation of application No. 14/858,539, filed on Sep. 18, 2015, granted, now 9,545,379, issued on Jan. 17, 2017.
Claims priority of provisional application 62/052,689, filed on Sep. 19, 2014.
Prior Publication US 2022/0040110 A1, Feb. 10, 2022
Int. Cl. A61K 9/16 (2006.01); A61K 35/16 (2015.01); B01J 19/06 (2006.01); B65D 51/30 (2006.01); B65D 81/26 (2006.01); F26B 3/04 (2006.01); F26B 3/06 (2006.01); F26B 3/12 (2006.01); F26B 5/04 (2006.01); F26B 5/06 (2006.01)
CPC A61K 9/1682 (2013.01) [A61K 9/16 (2013.01); A61K 9/1617 (2013.01); A61K 9/1688 (2013.01); A61K 35/16 (2013.01); B01J 19/06 (2013.01); F26B 3/04 (2013.01); F26B 3/06 (2013.01); F26B 3/12 (2013.01); F26B 5/04 (2013.01); B01J 2219/00177 (2013.01); B65D 51/30 (2013.01); B65D 81/266 (2013.01); F26B 5/065 (2013.01)] 30 Claims
 
1. A method of producing a formulated plasma for spray drying, the method comprising:
a) combining one or more stable acidic substances with plasma, wherein the concentration of the stable acidic substance is in a range between about 0.001 mmol/ml and about 0.050 mmol/ml, wherein said one or more stable acidic substances is an acid or acidic salt that effectuates a pH, to thereby create a formulated plasma.