US 12,064,514 B2
Ultrasound-sensitive peptide particles for spatially resolved molecule delivery
Joel P. Schneider, Frederick, MD (US); and Scott H. Medina, State College, PA (US)
Assigned to THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US); and THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH, Bethesda, MD (US)
Appl. No. 16/634,679
Filed by The Penn State Research Foundation, University Park, PA (US); and THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US)
PCT Filed Jul. 30, 2018, PCT No. PCT/US2018/044382
§ 371(c)(1), (2) Date Jan. 28, 2020,
PCT Pub. No. WO2019/023706, PCT Pub. Date Jan. 31, 2019.
Claims priority of provisional application 62/538,116, filed on Jul. 28, 2017.
Prior Publication US 2020/0197307 A1, Jun. 25, 2020
Int. Cl. C07K 7/08 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 47/65 (2017.01); C07K 7/06 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 9/1273 (2013.01) [A61K 9/0009 (2013.01); A61K 47/65 (2017.08); C07K 7/06 (2013.01); B82Y 5/00 (2013.01); C07K 2319/01 (2013.01)] 12 Claims
 
1. An amphiphilic peptide represented by Formula (III):
HB-CL-HP-NH2  (III)
wherein HB is a fluorinated hydrophobic block consisting of three to five consecutively connected pentafluorinated hydrophobic amino acid residues;
wherein CL is an amino acid sequence consisting of two to 10 amino acid residues, at least two of which are cross-linking cysteine residues;
wherein HP is a hydrophilic amino acid sequence, and
wherein said amphiphilic peptide consists of 8 to 30 total amino acid residues.