US 12,064,511 B2
Lipid nanoparticles containing silyl lipids for use in vaccines and gene therapy
Annaliese Franz, Davis, CA (US); Angel Cobo, Davis, CA (US); Leah Thompson, Davis, CA (US); and David Coppage, Davis, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Jan. 24, 2023, as Appl. No. 18/159,010.
Claims priority of provisional application 63/323,388, filed on Mar. 24, 2022.
Prior Publication US 2023/0301912 A1, Sep. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/127 (2006.01); A61K 31/7105 (2006.01)
CPC A61K 9/127 (2013.01) [A61K 31/7105 (2013.01)] 25 Claims
 
1. A preparation of lipid nanoparticles in which at least 5% of lipids in the nanoparticles are silyl lipids having the structure shown in Formula III or Formula IIIa:

OG Complex Work Unit Chemistry
wherein R1, R2, and R3 are independently H, —CH3, or a substituted or unsubstituted hydrocarbon containing two to ten carbon atoms,
X1 is nitrogen or —(OPO3)—,
X2 and X3 are independently methylene or carbonyl or together are a quaternary carbon;
W and W are independently selected from methyl and a hydrocarbon or substituted hydrocarbon of 4 to 12 carbon atoms;
R8a and R8b are independently methyl or a saturated or unsaturated hydrocarbon of 2 to 10 carbon atoms;
n1 is 1 to 6; and
n2, n3, n4 and n5 are independently 4 to 12.