US 12,064,487 B2
Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
Soizic Le Greneur, Bures-sur-Yvette (FR); Alain Chénedé, Lagord (FR); Martine Cerf, Breuil-Magné (FR); Myriam Petta, Montmorency (FR); Emmanuelle Marais, Le Chesnay (FR); Bruno François, Saint-Jean-de-Liversay (FR); Caroline Robic, Nogent-sur-Marne (FR); and Stéphanie Louguet, Le Kremlin-Bicêtre (FR)
Assigned to GUERBET, Villepinte (FR)
Filed by GUERBET, Villepinte (FR)
Filed on Jan. 16, 2023, as Appl. No. 18/154,894.
Application 18/154,894 is a continuation of application No. 17/423,638, granted, now 11,590,246, previously published as PCT/EP2020/051153, filed on Jan. 17, 2020.
Claims priority of application No. 1900432 (FR), filed on Jan. 17, 2019.
Prior Publication US 2023/0149568 A1, May 18, 2023
Int. Cl. A61K 49/10 (2006.01)
CPC A61K 49/106 (2013.01) 13 Claims
 
1. A method of medical imaging, the method comprising administering to a subject in need thereof a composition comprising:
1) a complex of formula (II) below:

OG Complex Work Unit Chemistry
having a diastereoisomeric excess of at least 80% of a mixture of isomers II-RRR and II-SSS of formulae:

OG Complex Work Unit Chemistry
and
2) a free macrocyclic ligand,
wherein the composition has a concentration of free gadolinium of less than 1 ppm (m/v), and
wherein the composition comprises from 0.002 to 0.4 mol/mol % of free macrocyclic ligand relative to the complex of formula (II).