CPC A61K 39/12 (2013.01) [A61K 39/39 (2013.01); A61P 31/14 (2018.01); C12N 7/00 (2013.01); A61K 2039/55 (2013.01); C12N 2770/24122 (2013.01); C12N 2770/24134 (2013.01); C12N 2770/24171 (2013.01)] | 17 Claims |
1. A method for preventing and/or treating a Zika viral infection in a subject in need thereof, the method comprising:
administering a therapeutically effective amount of an isolated polypeptide comprising an altered structural envelope (E) protein domain III (EDIII);
wherein the isolated polypeptide comprises any of SEQ ID NOs 4-6 or 8-22, or a combination thereof; and
wherein the alteration reduces or prevents the immunogenicity of one or more interfering epitopes of the EDIII.
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