	US 12,064,449 B2
	Compositions and methods for improvement of iron metabolism and gut microbiome health
Darren Wolfe, Cincinnati, OH (US); and James Connor, Hershey, PA (US)
Assigned to SIDERO BIOSCIENCE, LLC, Hummelstown, PA (US)
Appl. No. 16/972,090
Filed by Sidero Bioscience, LLC, Hummelstown, PA (US)
PCT Filed Jun. 4, 2019, PCT No. PCT/US2019/035437 § 371(c)(1), (2) Date Dec. 4, 2020, PCT Pub. No. WO2019/236611, PCT Pub. Date Dec. 12, 2019.
Claims priority of provisional application 62/680,238, filed on Jun. 4, 2018.
Prior Publication US 2021/0220396 A1, Jul. 22, 2021
Int. Cl. A61K 33/26 (2006.01); A23L 33/00 (2016.01); A23L 33/14 (2016.01); A23L 33/165 (2016.01); A23L 33/17 (2016.01); A61K 35/74 (2015.01); A61K 36/06 (2006.01)

CPC A61K 33/26 (2013.01) [A23L 33/14 (2016.08); A23L 33/165 (2016.08); A23L 33/17 (2016.08); A23L 33/30 (2016.08); A61K 35/74 (2013.01); A61K 36/06 (2013.01)]

28 Claims

1. A composition comprising (a) a microbe expressing mammalian H-ferritin or a homologue thereof and (b) elemental iron in an amount of at least 3% by weight on a dry matter basis of the microbe expressing mammalian H-ferritin or a homologue thereof and the elemental iron; wherein at least 60% of the elemental iron is complexed with the mammalian H-ferritin or the homologue thereof.