US 12,064,448 B2
Methods for reducing bioavailability and absorption of ingested substances
Philip Demokritou, Brookline, MA (US); Glen Deloid, Natick, MA (US); Kee Woei Ng, Singapore (SG); and Say Chye Joachim Loo, Singapore (SG)
Assigned to Nanyang Technological University, Singapore (SG); and President and Fellows of Harvard College, Cambridge, MA (US)
Appl. No. 16/762,845
Filed by Nanyang Technological University, Singapore (SG); and President and Fellows of Harvard College, Cambridge, MA (US)
PCT Filed Nov. 9, 2018, PCT No. PCT/US2018/060096
§ 371(c)(1), (2) Date May 8, 2020,
PCT Pub. No. WO2019/094769, PCT Pub. Date May 16, 2019.
Claims priority of provisional application 62/697,827, filed on Jul. 13, 2018.
Claims priority of provisional application 62/584,504, filed on Nov. 10, 2017.
Prior Publication US 2021/0030782 A1, Feb. 4, 2021
Int. Cl. A61K 31/717 (2006.01); A61K 9/14 (2006.01)
CPC A61K 31/717 (2013.01) [A61K 9/146 (2013.01)] 9 Claims
 
1. A method for reducing the bioavailability and/or absorption of ingested fat from foodstuff in a subject, the method comprising:
administering an amount of a suspension of a nanobiopolymer, or combinations of nanobiopolymers, sufficient to reduce the bioavailability ingested fat to a subject,
wherein the nanobiopolymer is selected from the group consisting of cellulose nanofibers or cellulose nanocrystals and combinations thereof,
wherein, when the nanobiopolymer is cellulose nanofibers, the nanobiopolymer comprises fibrillar nanocellulose made by mechanical milling and having a diameter of up to 100 nm,
wherein when the nanobiopolymer is cellulose nanocrystals, the cellulose nanocrystals comprise nanocrystalline cellulose made by chemical means and the nanocrystalline cellulose ranges in diameter from 1 nm to 250 nm and
further wherein the bioavailability of the ingested fat is reduced by at least 30%.