US 12,064,438 B2
Pharmaceutical preparation excellent in light stability and dissolution property
Naomi Hayashi, Hyogo (JP); Masato Gomi, Hyogo (JP); and Shohei Aikawa, Hyogo (JP)
Assigned to SHIONOGI & CO., LTD., Osaka (JP)
Appl. No. 16/764,067
Filed by Shionogi & Co., Ltd., Osaka (JP)
PCT Filed Nov. 15, 2018, PCT No. PCT/JP2018/042220
§ 371(c)(1), (2) Date May 14, 2020,
PCT Pub. No. WO2019/098259, PCT Pub. Date May 23, 2019.
Claims priority of application No. 2017-222068 (JP), filed on Nov. 17, 2017.
Prior Publication US 2020/0375998 A1, Dec. 3, 2020
Int. Cl. A61K 31/5383 (2006.01); A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61P 31/16 (2006.01)
CPC A61K 31/5383 (2013.01) [A61K 9/2054 (2013.01); A61K 9/2813 (2013.01); A61K 9/2846 (2013.01); A61K 9/2866 (2013.01); A61P 31/16 (2018.01)] 14 Claims
 
1. A solid preparation comprising:
a compound represented by the formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof,
croscarmellose sodium, and
a coating layer comprising at least one light-stabilizing substance and at least one polymer selected from the group consisting of hypromellose, polyvinyl alcohol and hydroxypropyl cellulose,
wherein the solid preparation is in the form of a tablet, and the tablet is coated by the coating layer.