	US 12,064,412 B2
	Method for preparing solution formulation for aerosol inhalation of naringenin
Mingyi Guan, Guangdong (CN); Weiwei Su, Guangdong (CN); and Hongliang Yao, Guangdong (CN)
Assigned to SUN YAT-SEN UNIVERSITY, Guangzhou (CN)
Appl. No. 16/976,728
Filed by SUN YAT-SEN UNIVERSITY, Guangdong (CN)
PCT Filed Aug. 28, 2019, PCT No. PCT/CN2019/102948 § 371(c)(1), (2) Date Aug. 28, 2020, PCT Pub. No. WO2020/252912, PCT Pub. Date Dec. 24, 2020.
Claims priority of application No. 201910541928.3 (CN), filed on Jun. 21, 2019.
Prior Publication US 2023/0110326 A1, Apr. 13, 2023
Int. Cl. A61K 31/352 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/40 (2006.01)

CPC A61K 31/352 (2013.01) [A61K 9/0078 (2013.01); A61K 9/08 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/186 (2013.01); A61K 47/40 (2013.01)]

7 Claims

1. A method for preparing a solution formulation for aerosol inhalation of naringenin, wherein the formulation is prepared from the following components: 1 part by weight of naringenin, 15-30 parts by weight of hydroxypropyl β-cyclodextrin and a buffer salt and an excipient, wherein the method comprises the steps of: preparing a buffer-salt solution of a pH value of 7-8.5 by using the buffer salt, adding the naringenin into the buffer-salt solution, then adding the hydroxypropyl β-cyclodextrin, shaking in a constant-temperature air bath till complete dissolving and coating, adding the excipient, and dissolving the excipient.